{"id":4077,"date":"2006-01-01T00:00:00","date_gmt":"2005-12-31T23:00:00","guid":{"rendered":"https:\/\/www.ardentis.ch\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/"},"modified":"2026-03-10T15:05:15","modified_gmt":"2026-03-10T14:05:15","slug":"central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst","status":"publish","type":"publication","link":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/","title":{"rendered":"Central giant cell granuloma misdiagnosed as odontogenic cyst."},"content":{"rendered":"\n<p><strong>Authors<\/strong><\/p>\n<p>Lombardi T., Bischof M., Nedir R., Vergain D., Galgano C., Samson J., K\u00fcffer R.<\/p>\n\n<p><strong>Title<\/strong><\/p>\n<p>Central giant cell granuloma misdiagnosed as odontogenic cyst.<\/p>\n\n<p><strong>Journal<\/strong><\/p>\n<p>International Endodontic Journal 39:510-515, 2006<\/p>\n\n<p><strong>Abstract<\/strong><\/p>\n<p>Abstract\n\nAim\nTo present the clinicopathological features of a series of four periapically located central giant cell granulomas (CGCGs) that were misdiagnosed and treated as being of endodontic origin.\n\nSummary\nFour cases of periapical CGCGs were submitted with a clinical diagnosis of either radicular or residual cyst. In two cases, root canal treatment had been performed previously. The patients were two women and two men whose age ranged from 31 to 85 years. Two cases were located in the mandibular premolar\u2013molar region, and two in the anterolateral region of the maxilla. Two lesions were submitted for histological examination with a diagnosis of radicular cyst, whereas the remaining two were submitted with a diagnosis of residual cyst.\n\nKey learning points\n\u2022 Periapical giant cell lesions may be unilocular and therefore misdiagnosed as an endodontic lesion because of their radiographic similarity to an inflammatory periradicular lesion, especially if the teeth have been root filled or if the vitality is negative or doubtful.\n\u2022 It is important to follow up the healing process of a periapical radiolucency related to a root-filled tooth and, in case of persistence, to perform surgery and to submit the specimen for histological examination.<\/p>\n\n<p><strong>Keywords<\/strong><\/p>\n<p>Keywords: central giant cell granuloma, periapical disease, radicular cyst, residual cyst.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Authors Lombardi T., Bischof M., Nedir R., Vergain D., Galgano C., Samson J., K\u00fcffer R. Title Central giant cell granuloma misdiagnosed as odontogenic cyst. Journal International Endodontic Journal 39:510-515, 2006 Abstract Abstract Aim To present the clinicopathological features of a series of four periapically located central giant cell granulomas (CGCGs) that were misdiagnosed and treated [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":5214,"template":"","meta":{"video_url":"","sticky":false},"publication_tag":[],"class_list":["post-4077","publication","type-publication","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Central giant cell granuloma misdiagnosed | Ardentis<\/title>\n<meta name=\"description\" content=\"Central giant cell granuloma misdiagnosed as odontogenic cyst.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Central giant cell granuloma misdiagnosed | Ardentis\" \/>\n<meta property=\"og:description\" content=\"Central giant cell granuloma misdiagnosed as odontogenic cyst.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/\" \/>\n<meta property=\"og:site_name\" content=\"Ardentis\" \/>\n<meta property=\"article:modified_time\" content=\"2026-03-10T14:05:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"ScholarlyArticle\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/\"},\"author\":{\"name\":\"Ardentis\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#\\\/schema\\\/person\\\/39940dbfaeb088f7342e9d0700090516\"},\"headline\":\"Central giant cell granuloma misdiagnosed as odontogenic cyst.\",\"datePublished\":\"2005-12-31T23:00:00+00:00\",\"dateModified\":\"2026-03-10T14:05:15+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/\"},\"wordCount\":243,\"publisher\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2006\\\/01\\\/AP_00888-scaled.jpg\",\"inLanguage\":\"en-US\"},{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/\",\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/\",\"name\":\"Central giant cell granuloma misdiagnosed | Ardentis\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2006\\\/01\\\/AP_00888-scaled.jpg\",\"datePublished\":\"2005-12-31T23:00:00+00:00\",\"dateModified\":\"2026-03-10T14:05:15+00:00\",\"description\":\"Central giant cell granuloma misdiagnosed as odontogenic cyst.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2006\\\/01\\\/AP_00888-scaled.jpg\",\"contentUrl\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2006\\\/01\\\/AP_00888-scaled.jpg\",\"width\":2560,\"height\":1707,\"caption\":\"Open magazine with eyeglasses, highlighting Ardentis's focus on dental and eye health solutions.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/publications\\\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Central giant cell granuloma misdiagnosed as odontogenic cyst.\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#website\",\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/\",\"name\":\"Ardentis\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#organization\",\"name\":\"Ardentis\",\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/logo.svg\",\"contentUrl\":\"https:\\\/\\\/www.ardentis.ch\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/logo.svg\",\"width\":154,\"height\":40,\"caption\":\"Ardentis\"},\"image\":{\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#\\\/schema\\\/logo\\\/image\\\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.ardentis.ch\\\/en\\\/#\\\/schema\\\/person\\\/39940dbfaeb088f7342e9d0700090516\",\"name\":\"Ardentis\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g\",\"caption\":\"Ardentis\"},\"url\":\"https:\\\/\\\/www.ardentis.ch\\\/en\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Central giant cell granuloma misdiagnosed | Ardentis","description":"Central giant cell granuloma misdiagnosed as odontogenic cyst.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/","og_locale":"en_US","og_type":"article","og_title":"Central giant cell granuloma misdiagnosed | Ardentis","og_description":"Central giant cell granuloma misdiagnosed as odontogenic cyst.","og_url":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/","og_site_name":"Ardentis","article_modified_time":"2026-03-10T14:05:15+00:00","twitter_card":"summary_large_image","twitter_misc":{"Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"ScholarlyArticle","@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#article","isPartOf":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/"},"author":{"name":"Ardentis","@id":"https:\/\/www.ardentis.ch\/en\/#\/schema\/person\/39940dbfaeb088f7342e9d0700090516"},"headline":"Central giant cell granuloma misdiagnosed as odontogenic cyst.","datePublished":"2005-12-31T23:00:00+00:00","dateModified":"2026-03-10T14:05:15+00:00","mainEntityOfPage":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/"},"wordCount":243,"publisher":{"@id":"https:\/\/www.ardentis.ch\/en\/#organization"},"image":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2006\/01\/AP_00888-scaled.jpg","inLanguage":"en-US"},{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/","url":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/","name":"Central giant cell granuloma misdiagnosed | Ardentis","isPartOf":{"@id":"https:\/\/www.ardentis.ch\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#primaryimage"},"image":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#primaryimage"},"thumbnailUrl":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2006\/01\/AP_00888-scaled.jpg","datePublished":"2005-12-31T23:00:00+00:00","dateModified":"2026-03-10T14:05:15+00:00","description":"Central giant cell granuloma misdiagnosed as odontogenic cyst.","breadcrumb":{"@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#primaryimage","url":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2006\/01\/AP_00888-scaled.jpg","contentUrl":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2006\/01\/AP_00888-scaled.jpg","width":2560,"height":1707,"caption":"Open magazine with eyeglasses, highlighting Ardentis's focus on dental and eye health solutions."},{"@type":"BreadcrumbList","@id":"https:\/\/www.ardentis.ch\/en\/publications\/central-giant-cell-granuloma-misdiagnosed-as-odontogenic-cyst\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Accueil","item":"https:\/\/www.ardentis.ch\/en\/"},{"@type":"ListItem","position":2,"name":"Central giant cell granuloma misdiagnosed as odontogenic cyst."}]},{"@type":"WebSite","@id":"https:\/\/www.ardentis.ch\/en\/#website","url":"https:\/\/www.ardentis.ch\/en\/","name":"Ardentis","description":"","publisher":{"@id":"https:\/\/www.ardentis.ch\/en\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.ardentis.ch\/en\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.ardentis.ch\/en\/#organization","name":"Ardentis","url":"https:\/\/www.ardentis.ch\/en\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.ardentis.ch\/en\/#\/schema\/logo\/image\/","url":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2025\/07\/logo.svg","contentUrl":"https:\/\/www.ardentis.ch\/wp-content\/uploads\/2025\/07\/logo.svg","width":154,"height":40,"caption":"Ardentis"},"image":{"@id":"https:\/\/www.ardentis.ch\/en\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.ardentis.ch\/en\/#\/schema\/person\/39940dbfaeb088f7342e9d0700090516","name":"Ardentis","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/8a819110b724233019a21fb09003eb7ee6586a375837eced50004a7676237ea7?s=96&d=https%3A%2F%2Fwww.ardentis.ch%2Fwp-content%2Fuploads%2F2026%2F03%2FAvatar-site-2-150x150.jpg&r=g","caption":"Ardentis"},"url":"https:\/\/www.ardentis.ch\/en"}]}},"_links":{"self":[{"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/publication\/4077","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/publication"}],"about":[{"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/types\/publication"}],"author":[{"embeddable":true,"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/users\/2"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/media\/5214"}],"wp:attachment":[{"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/media?parent=4077"}],"wp:term":[{"taxonomy":"publication_tag","embeddable":true,"href":"https:\/\/www.ardentis.ch\/en\/wp-json\/wp\/v2\/publication_tag?post=4077"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}